diff --git a/ports/seqan/portfile.cmake b/ports/seqan/portfile.cmake
index c265da680f..6541847f14 100644
--- a/ports/seqan/portfile.cmake
+++ b/ports/seqan/portfile.cmake
@@ -1,14 +1,14 @@
-vcpkg_download_distfile(ARCHIVE
-    URLS "http://packages.seqan.de/seqan-library/seqan-library-2.4.0.zip"
-    FILENAME "seqan-library-2.4.0.zip"
-    SHA512 9a1b4fe9dff9ad49a8761798a6a6eaeebce683ccb5e2dd78ea4b8829093918606830a16ea458d67bf3f652531ddc55b550c12cb257be913bb187c8940d96a575
-)
-
-vcpkg_extract_source_archive(
-    SOURCE_PATH
-    ARCHIVE ${ARCHIVE}
-)
-
-file(INSTALL ${SOURCE_PATH}/include DESTINATION ${CURRENT_PACKAGES_DIR} FILES_MATCHING PATTERN "*.h")
-
-file(INSTALL ${SOURCE_PATH}/share/doc/seqan/LICENSE DESTINATION ${CURRENT_PACKAGES_DIR}/share/seqan RENAME copyright)
+vcpkg_download_distfile(ARCHIVE
+    URLS "https://github.com/seqan/seqan/releases/download/seqan-v${VERSION}/seqan-library-${VERSION}.zip"
+    FILENAME "seqan-library-${VERSION}.zip"
+    SHA512 de62c69bfacf758df8f3dde11a12f4f54b145e18da8aba859f5e4a569f8969aa45a3dd5db6dda0b0970bb8bc088804ceb7a80ec4a85cea0c97a6d437851801e1
+)
+
+vcpkg_extract_source_archive(
+    SOURCE_PATH
+    ARCHIVE ${ARCHIVE}
+)
+
+file(INSTALL ${SOURCE_PATH}/include DESTINATION ${CURRENT_PACKAGES_DIR} FILES_MATCHING PATTERN "*.h")
+
+file(INSTALL ${SOURCE_PATH}/share/doc/seqan/LICENSE DESTINATION ${CURRENT_PACKAGES_DIR}/share/seqan RENAME copyright)
diff --git a/ports/seqan/vcpkg.json b/ports/seqan/vcpkg.json
index bc89f206c9..33c3206c00 100644
--- a/ports/seqan/vcpkg.json
+++ b/ports/seqan/vcpkg.json
@@ -1,6 +1,6 @@
 {
   "name": "seqan",
-  "version": "2.4.0",
-  "port-version": 3,
-  "description": "SeqAn is an open source C++ library of efficient algorithms and data structures for the analysis of sequences with the focus on biological data."
+  "version": "2.5.3",
+  "description": "SeqAn is an open source C++ library of efficient algorithms and data structures for the analysis of sequences with the focus on biological data.",
+  "homepage": "https://www.seqan.de"
 }
diff --git a/versions/baseline.json b/versions/baseline.json
index 518d14ab71..84fcd03556 100644
--- a/versions/baseline.json
+++ b/versions/baseline.json
@@ -9113,8 +9113,8 @@
       "port-version": 5
     },
     "seqan": {
-      "baseline": "2.4.0",
-      "port-version": 3
+      "baseline": "2.5.3",
+      "port-version": 0
     },
     "serd": {
       "baseline": "0.32.8",
diff --git a/versions/s-/seqan.json b/versions/s-/seqan.json
index 3aff9bf3a1..6c41bcc240 100644
--- a/versions/s-/seqan.json
+++ b/versions/s-/seqan.json
@@ -1,5 +1,10 @@
 {
   "versions": [
+    {
+      "git-tree": "bbb4cb5eb8d43af176c9662959cb91d6a72df6b8",
+      "version": "2.5.3",
+      "port-version": 0
+    },
     {
       "git-tree": "d9c24c4c48a7664bc9b685cd6c931d534ff6164b",
       "version": "2.4.0",